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KMID : 0903520060490040270
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2006 Volume.49 No. 4 p.270 ~ p.275
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2β, 3α, 23-trihydroxyrus-12-ene-28-oic Acid Induces the Apoptosis of Human Hepatoma HepG2 Cells
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Yoo Ki-Hyun
Lee Jong-Min
Hwangbo-Jeon
Song Myoung-Chong
Yang Hye-Joung
Baek Nam-In
Kim Sung-Hoon
Kim Dae-Keun
Kwon Byoung-Mog
Park Mi-Hyun
Chung In-Sik
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Abstract
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2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid was isolated from Trapa pseudoincisa S. et Z. It has a common structure of pentacyclic triterpenes and belongs to the amyrin ursolic acid group. The cytotoxic effect of this compound was investigated in human hepatoma cell line HepG2. 2β, 3α, 23- trihydroxyrus-12-ene-28-oic acid showed dose-dependent cytotoxicity in HepG2 cells. Confocal microscopy data showed that green fluorescence was increased in 2β, 3α, 23-trihydroxyrus-12-ene- 28-oic acid treated-HepG2 cells in a time-dependent manner. 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid also increased the sub-G1 cell population of HepG2 cells as well as ladder-like DNA fragmentation. Taken together, our results indicate that 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induced apoptosis in HepG2 cells.
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KEYWORD
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2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid, HepG2, apoptosis, cytotoxicity
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